IL-36 in inflammatory diseases
10.3969/j.issn.1000-484X.2018.03.033
- VernacularTitle:IL-36在炎性疾病中的研究进展
- Author:
Mei LI
1
;
Tian-Pen CUI
Author Information
1. 湖北中医药大学检验学院
- Keywords:
IL-36 family cytokines;
Immune function;
Inflammatory diseases
- From:
Chinese Journal of Immunology
2018;34(3):478-480,封3
- CountryChina
- Language:Chinese
-
Abstract:
The IL-36,which is a member of IL-1 family,consists of three ligands IL-36α,IL-36β and IL-36γ. The cytokines exert their proinflammatory effects through a specific IL-36 receptor(IL-36R),IL-36Ra is an antagonist of IL-36R.IL-36 acts as a helper,involved in dendritic cell and T cell activation, maturation, polarization, antigen presentation and stimulating inflammatory factor production,and so on.IL-36,as a new proinflammatory factor,plays a very important role in many inflammation diseases, including psoriasis,inflammatory bowel disease,arthritis,SLE,lung diseases and so on.
