Research progress of tertiary lymphoid tissues in multiple sclerosis
10.3969/j.issn.1000-484X.2018.03.030
- VernacularTitle:三级淋巴组织在多发性硬化中的研究进展
- Author:
Rui-Kai CHAI
1
;
Hu-Lun LI
Author Information
1. 哈尔滨医科大学神经生物教研室
- Keywords:
Tertiary lymphoid tissues(TLTs);
Multiple sclerosis(MS);
Experimental autoimmune encephalomyelitis (EAE)
- From:
Chinese Journal of Immunology
2018;34(3):463-467
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,it has been found that there are lymphoid follicle structures outside the lymphoid tissues and organs, which are called ectopic lymphoid tissues,also known as tertiary lymphoid tissues(TLTs).TLTs currently have been found in a number of diseases such as multiple sclerosis,diabetes,cancer,atherosclerosis and rheumatoid arthritis and the like.Here we focus on the molecular mechanism of TLTs and the relationship between TLTs and multiple sclerosis (MS)/experimental autoimmune encephalomyelitis (EAE) disease,and briefly describe the role of TLTs in the development of MS/EAE,the relevant mechanisms and research progress,make people have more understanding and insights on the formation of TLTs and the mechanism that it involved in disease,to provid theoretical knowledge for clinical treatment.
