Progress on exosome and effect on regulatory T cells
10.3969/j.issn.1000-484X.2018.03.027
- VernacularTitle:外泌体及其对调节性T细胞作用的研究进展
- Author:
Shao-Peng ZHANG
1
;
Xu-Hao NI
;
Ling LÜ
Author Information
1. 南京医科大学第一附属医院,南京210029
- Keywords:
Exosomes;
CD4+CD25+FOXP3+Treg cells;
RNA;
Dendritic cell;
Tumor cell
- From:
Chinese Journal of Immunology
2018;34(3):450-453,459
- CountryChina
- Language:Chinese
-
Abstract:
Regulatory T (Treg) cells is an indispensable subset of T lymphocyte with the ability of immunosuppression in the periphery.Thymus-derived Treg cells(CD4+CD25+FOXP3+Treg cells) play a fundamental role in maintaining immune homeostasis in vivo.Treg cells have been actively involved in the onset and development of major human diseases including malignant tumors, autoimmune diseases,infectious diseases,allergic diseases and graft versus host disease(GVHD).Exosomes are membranous vesicles of endosomal origin that released from multiple cells into the extracellular space.They are currently considered to be vehicles containing protein,RNA and MicroRNA which can been transferred to recipient cells to modulate their activity by cell-contact-independent mecha-nism.Exosomes have a great impact on the induction and proliferation of Treg cells,understanding the relation of them will lead to novel therapeutic approaches for cancer immunotherapy,treating autoimmunity,infection,allergy and organ transplantation.
