Significance of serum IgG4 and CA19-9 in diagnosis and antidiastole of IgG4 related cholangitis
10.3969/j.issn.1000-484X.2018.03.023
- VernacularTitle:血清IgG4、CA19-9水平对IgG4相关性胆管炎的诊断及鉴别诊断价值
- Author:
Li-Ming TAN
1
;
Xiao-Lin GUAN
;
Si-Fan WU
;
Wei ZHENG
;
Hui-Ying FU
;
Yi-Mei MENG
;
Ting-Ting LONG
;
Qiao-Hua WANG
;
Yang WU
;
Ting-Ting ZENG
;
Yong-Jian TIAN
;
Jian-Lin YU
;
Juan-Juan CHEN
;
Hua LI
;
Li-Ping CAO
;
Hui XU
Author Information
1. 南昌大学第二附属医院检验科
- Keywords:
IgG4-associated cholangitis;
Primary sclerosing cholangitis;
Bile duct cancer;
Pancreatic cancer;
IgG4;
CA19-9;
Antinuclear antibodies (ANA);
Anti neutrophil antibodies (ANCA);
Anti smooth muscle antibodies (SMA);
Anti mitochondrial antibodies (AMA)
- From:
Chinese Journal of Immunology
2018;34(3):431-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of autoantibodies and serum levels of IgG4 and CA19-9 in the diagnosis of IgG4 associated cholangitis (IgG4-SC).Methods:Detect the serum IgG4 and CA19-9 of 41 clinical cases of IgG4-SC patients,162 clinical cases of non IgG4-SC patients and 40 healthy human serum samples by immunoassay and direct chemiluminescence methods, also detect the antinuclear antibodies (ANA),anti neutrophil antibody (ANCA),anti smooth muscle antibody (SMA) and anti mitochondrial antibody (AMA) of the above serum samples by indirect immunofluorescence and analyze the detection results.Results:①The positive rates of ANA,ANCA,SMA and AMA in patients with IgG4-SC were 41.46%,7.32%,0 and 2.44%.Among them,the positive rate of ANA was significantly different from that of the normal control group(P<0.01),and the positive rate of SMA and AMA was significantly different from that of non IgG4-SC group(P<0.01),and so as the positive rate of ANCA do with that of PSC group.②The number of serum IgG4 and CA19-9 increased samples were significantly compared with the normal control group (P<0.01);the area under the ROC curve (AUC) was 0.979 and 0.646,respectively,and P<0.05.Conclusion:The high level of serum IgG4 and CA19-9 and autoantibody detection are of great accuracy and important clinical value in the differential diagnosis of IgG4-SC.
