Expression of IL-21/BCL-6/Blimp-1 in echinococcosis
10.3969/j.issn.1000-484X.2018.03.019
- VernacularTitle:IL-21/BCL-6/Blimp-1在囊性包虫病中的表达特点研究
- Author:
Xin-Hui GENG
1
;
Feng-Bo ZHANG
;
Min JIANG
;
Hui ZHAO
;
Meng-Ting AN
;
Nan-Nan PANG
;
Hong-Ying WANG
;
Jian-Bing DING
Author Information
1. 新疆医科大学第二附属医院检验科
- Keywords:
Cystic echinococcosis (CE);
Interleukin-21(IL-21);
B lymphocyte induced mature protein 1 (Blimp-1);
Molecular 6 B cell lymphoma (BCL-6)
- From:
Chinese Journal of Immunology
2018;34(3):412-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of IL-21/BCL-6/Blimp-1 in CE patients and discusse the mechanism of the pathogenesis of the echinococcosis.Methods:27 patients and 30 health persons were collected from the first affiliated hospital of Xinjiang medical university in the same period.IL-21 was detected by ELISA and the expression of IL-21/BCL-6 /Blimp-1 mRNA was detected by Real-time fluorescence quantitative PCR (qRT-PCR) in CE patients.At the same time,17 patients were followed up in the group of patients,and the expression of IL-21/BCL-6/Blimp-1 was detected before and after treatment.Results:(1) The results of PCR showed that the levels of IL-21/BCL-6 mRNA were significantly increased in the peripheral blood mononuclear cells of the CE patients compared with the healthy control group (P<0.05).The expression of IL-21/BCL-6 /Blimp-1 mRNA in patients before the treatment was higher than that of patients after treatment(P<0.05).(2)The level of IL-21 in peripheral blood of CE patients was sig-nificantly higher than that in the healthy control group and basically returned to normal after the cure (P<0.05).IL-21 was positively correlated with BCL-6(r=0.733, P<0.01).Conclusion:BCL-6 and Blimp-1 May promote the human immune system to resist parasitic infection in the course of the development of the disease.IL-21, BCL-6 and Blimp-1 are significantly reduced after effective treatment,indicating that these factors are involved in the immune mechanism of the development of the disease.
