Advances in research of mannan-binding lectin-associated serine protease 3
10.3969/j.issn.1000-484X.2018.02.033
- VernacularTitle:甘露聚糖结合凝集素相关丝氨酸蛋白酶3的研究现状
- Author:
Min WEI
1
;
Guo-Lan XING
Author Information
1. 郑州大学第一附属医院,郑州450052
- Keywords:
MASP3;
Complement factor D;
Complement alternative pathway;
Alternative pathway-mediated disease
- From:
Chinese Journal of Immunology
2018;34(2):317-320,封3
- CountryChina
- Language:Chinese
-
Abstract:
MASP3 is one of the mannan-binding lectin-associated serine proteases(MASPs)of the complement lectin pathway.It is the alternative splice product of MASP1/3 gene.MASP3 does not participate in the activation of the lectin pathway and it has no cleavage activity towards C2,C4 and C3.Recently,a novel MASP3 function has been discovered that it may play an important role in the alternative pathway through direct activation of factor D.Besides,studies on the murine disease model suggested that MASP3 might be a new therapeutic target for the treatment of alternative pathway-mediated diseases.This review present an overall description of the coding gene and protein structure of MASP3 protein and provide recent research progress on its function and especially in its role in the alternative pathway-mediated diseases.
