Value of procalcitonin and C-reactive protein in discriminating bloodstream infection bacterial species
10.3969/j.issn.1000-484X.2018.02.017
- VernacularTitle:降钙素原、C-反应蛋白在鉴别血流感染菌属中的应用价值
- Author:
Hong-Wei YU
1
;
Kuo CHENG
;
Wei-Li MA
;
Jing HE
;
Yan LI
;
Jin-Yan ZHANG
Author Information
1. 河北医科大学第四医院检验科
- Keywords:
Bloodstream infection;
Bacteremia;
Procalcitonin;
C-reactive protein
- From:
Chinese Journal of Immunology
2018;34(2):243-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of procalcitonin (PCT),C-reactive protein (CRP) in discriminating the bloodstream infection bacterial species,and to analyze the levels of PCT and CRP in sepsis caused by different pathogens.Methods:Patients with blood culture and PCT,CRP detection were collected in the study,from January 2015 to January 2017.The levels of PCT and CRP were detected with electrochemiluminescence and immunoturbidimetric,respectively.The levels of PCT in gram positive bacteria and gram negative bacteria,different bacterial species were compared by SPSS21.0 statistical software.Receiver operating characteristic(ROC) curve was established by Sigma software,calculating the optimal cutoff value.Results:The difference in the levels of PCT between gram positive bacteria and gram negative bacteria was statistically significant,and the value of U was 4 420.00,(P=0.004).ROC analysis showed the optimal cut-off value was 1.105 ng/ml.The levels of PCT had statistically significant difference in coagulase-positive staphylococci and coagulase-negative staphylococci,and the value of U was 79.00(P<0.001).ROC analysis revealed the optimal cut-off value of 0.870 ng/ml.There was a significant difference in the levels of PCT in Enterobacteriaceae and non fermentative bacteria and the value of U was 681.50(P=0.005).ROC analysis showed the optimal cutoff value was 3.310 ng/ml.There was no significant difference in PCT between Staphylococcus and Enterococcus.The levels of CRP was no significant difference between the groups.Conclusion:Detection of PCT has certain value in discriminating of bloodstream infection by different bacterial species,which can provide the basis for the early rational use of drugs in patients with suspected bacteremia.The detection of PCT combined with the blood culture,can reduce the risk of failure in patients with severe infection,and improve the efficiency of treatment.
