Research progress of mechanism of anti-NMDA-receptor antibodies in NPSLE
10.3969/j.issn.1000-484X.2018.01.027
- VernacularTitle:抗NMDA受体抗体在神经精神狼疮发病机制中的研究进展
- Author:
Hao LIAO
1
;
Wen-Di PEI
Author Information
1. 南方医科大学珠江医院
- Keywords:
NSPLE;
Anti-NMDA-receptor antibodies;
Mechanism;
Inflammatory mediator
- From:
Chinese Journal of Immunology
2018;34(1):137-140,143
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus (SLE)is an autoimmune disease,involving multiple organs and systems,and it is defined as neuropsychiatric systemic lupus erythematosus (NPSLE) when neuropsychiatric symptoms appear.The N-methyl-D-aspartate (NMDA) receptor is a kind of membrane-spanning ion channels' glutamate receptors,which mainly contains NR1 subunit and NR2 subunit.In recent years,the role of anti-NMDA-receptor antibodies in the pathogenesis of NPSLE has become a research hotspot,especially for anti-NR2 antibody.Therefore we review the research progress of the mechanism of the anti-NMDA-receptor antibodies in NPSLE in this paper.
