Novel mechanisms of CTLA-4 inhibition on bone remodeling
10.3969/j.issn.1000-484X.2018.01.026
- VernacularTitle:CTLA-4在骨重建中发挥免疫调节作用的研究进展
- Author:
Wen-Qiang MA
1
;
Ya QIU
;
Li-Zhong SUN
;
Lin-Xuan WANG
;
Mei HAN
;
Fang-Lin MI
Author Information
1. 川北医学院附属医院
- Keywords:
CTLA-4;
Bone remodeling;
Osteoclast;
Inflammatory response;
Cytokines
- From:
Chinese Journal of Immunology
2018;34(1):132-136
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the CTLA-4 immunoglobulin biologics,a negative regulator in the immune system,have been obtained due attention in autoimmune diseases,transplantation rejection,and antineoplastic agents.CTLA-4 can inhibit T cell activation,reduce the expression of RANKL and other cytokines through regulating immune response,and effectively alleviate the process of bone resorption.According to previous study,CTLA-4 was involved in osteoclast-induced bone destruction and bone remodeling.In this review,the effect of CTLA-4 on the autoimmune diseases,on the osteoclast formation,and on the alveolar bone remodeling in the periodontal tissue was involved,and the related research were also evaluated to look forward to possible future basic research and clinical application direction.
