Research progress of role of NLRP3 inflammasome in lupus nephritis
10.3969/j.issn.1000-484X.2018.01.025
- VernacularTitle:NLRP3炎症小体在狼疮性肾炎中作用的研究进展
- Author:
Tong-Sheng HUANG
1
;
Yun GUO
;
Chen YANG
;
Ning AN
;
Hua-Feng LIU
Author Information
1. 广东医科大学肾病研究所
- Keywords:
Systemic lupus erythematosus;
NLRP3 inflammasome;
Kindey injury;
Specific treatment
- From:
Chinese Journal of Immunology
2018;34(1):127-131
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus (SLE)is an autoimmune disease whose pathogenesis is extremely complicated.With the further research,the role of inflammasome in the pathogenesis of Lupus nephritis has also been gradually emphasized.Among them,the nucleotide-binding oligomerization domain-like receptors family pyrin domain containing 3 (NLRP3) inflammasome is the most exhaustive inflammasome.We summarize the related studies on the role of NLRP3 inflammasome in Lupus nephritis in recent years.We found that NLRP3 inflammasome not only plays an important role in the pathogenesis of Lupus nephritis,but also participates in the process of kidney injury by circulating immune cells and renal innate cells.Finally,we introduced two specific inhibitors of NLRP3 inflammasome,β-hydroxybutyrate and MCC950,which provided a new strategy for the treatment of Lupus nephritis.
