Clinical characteristics of carbapenem-resistant Klebsiella pneumoniae bloodstream infection and the risk factors of mortality
10.16718/j.1009-7708.2018.02.004
- VernacularTitle:碳青霉烯类耐药肺炎克雷伯菌血流感染的临床特征与死亡危险因素分析
- Author:
Xiuwen YANG
1
;
Junchang CUI
;
Jin ZHAO
;
Wentao NI
Author Information
1. 中国人民解放军总医院呼吸内科
- Keywords:
carbapenem-resistant;
Klebsiella pneumoniae;
bloodstream infection;
risk factor;
mortality
- From:
Chinese Journal of Infection and Chemotherapy
2018;18(2):142-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics, risk factors of mortality and antimicrobial therapy of carbapenemresistant Klebsiella pneumoniae (CRKP) bloodstream infections. Methods A 5-year retrospective study was conducted for 60 patients with CRKP bloodstream infection, who were treated in Chinese People's Liberation Army (PLA) General Hospital during the period from June 2011 to August 2016. The patients were assigned to death (n=24) or survival (n=36) group according to 28-day survival after bloodstream infection to identify the predictors of mortality. The patients treated with combination antimicrobial therapy (n=32) were compared with those received monotherapy (n=14). Results A total of 60 nonduplicate CRKP blood isolates were identified. The 28-day mortality was 40.0％ (24/60). High APACHE Ⅱ score (OR=1.15, 95％ CI 1.0-1.3, P=0.048) was identified as an independent risk factor for 28-day mortality in patients with CRKP bloodstream infection. The 46 patients receiving antimicrobial therapy showed 28-day mortality of 34.8％. Univariate analysis indicated that the 28-day mortality rate was similar between the patients receiving combination antimicrobial therapy and those receiving monotherapy. Conclusions Bloodstream infection due to CRKP is associated with high mortality. APACHE II score is an independent predictor for mortality in patients with CRKP bloodstream infection.
