Effects of long-term physical exercise on learning and memory impairment induced by recurrent seizures in neonatal rats
10.3969/j.issn.1001-1242.2018.06.007
- VernacularTitle:长程的运动训练对新生期大鼠反复惊厥所致学习和记忆损害的影响
- Author:
Shengming XIE
1
;
Xiaoyan SHI
;
Hong NI
Author Information
1. 苏州大学附属儿童医院
- Keywords:
convulsion;
morris water maze;
physical exercise;
learning and memory
- From:
Chinese Journal of Rehabilitation Medicine
2018;33(6):653-657
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore effects of early long-term exercise training on learning and memory impairment induced by recurrent seizures in neonatal rats.Method:Eighteen Sprague-Dawley rats at postnatal days 8 (P8) were randomly divided into control group (CONT),convulsion group (EXP1),and convulsion plus physical exercise group (EXP2)(Six in each group).Rats were fed for 1 day before the study.From P9,rats in EXP1 and EXP2 were subjected to flurothyl induced recurrent seizures 30min daily for 7 days.The rats of EXP2 were physical exercise from P16 to P57.The rats in control group were placed into the container for an equal amount of time to their counterpart without exposing to flurothyl.On P58-P64,subjects of the three groups were tested with Morris water maze.Result:①Place navigation test:there were significant differences among three groups [F=429.90,P＜0.05],day [F=282.30,P＜0.05],interaction [F=12.71,P＜0.05] by repeated two-way ANOVA analysis.Compared with CONT group,the escape latency in EXP1 was longer (P＜0.05).Compared with EXP1,the escape latency in EXP2 was shorter (P＜ 0.05).②Spatial probe test:Compared with CONT group,the frequency of passing through the platform in EXP1 was much less (P＜0.05).While compared with EXP1,the frequency of passing through the platform in EXP2 was much more (P ＜ 0.05).Conclusion:Physical exercise could significantly reduce the escape latency time and increase the number of crossing the platform in the recurrent seizure group,which may be due to the improvement of learning and memory ability of convulsive rats by physical exercise.
