Intermittent aerobic exercise decreases blood pressure of hypertensive nephropathy rat by up-regulated expression of adrenomedullin
10.3969/j.issn.1001-1242.2018.01.007
- VernacularTitle:间歇有氧运动通过上调高血压肾病大鼠肾上腺髓质素降低血压机制的研究
- Author:
Hongwei LI
1
;
Ping DUAN
;
Min LAI
Author Information
1. 赣南师范大学体育学院
- Keywords:
intermittent aerobic exercise;
hypertensive nephropathy rat;
adrenomedullin;
specificity receptor of adrenomedullin
- From:
Chinese Journal of Rehabilitation Medicine
2018;33(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To probe the effect of intermittent aerobic exercise on adrenomedullin secretion of kidney in hypertensive nephropathy rat (HNR),and investigate the renal mechanism for exercise in the prevention and treatment of hypertension.Method:Thirty-two HNRs were divided into two groups:intermittent exercise group (Group IAE) and control group (Group C).The IAE group performed intermittent treadmill exercise for 8 weeks and their blood pressure was measured before and after exercise by tail pressure of HNR,and serum ADM was detected by enzyme linked immunosorbent assay.Adrenomedullin (ADM) was expressed in kidney by immunohistochemistry.Quantification of specific receptor RAMP2 and CRLR in kidney ADM was detected by immunoblotting.Result:The blood pressure in the Group IAE was significantly lower than that in the Group C(P＜ 0.05).The expression of ADM of kidney and serum in the Group IAE was obviously higher than that in the Group C.The quantity of RAMP2 and CRLR in kidney was obviously increased(P ＜ 0.05).Conclusion:Intermittent aerobic exercise increases serum ADM of HNR with the up-regulated expression of ADM in kidney and their specific receptor CRLR and RAMP2.The increase of serum ADM induced by intermittent aerobic exercise may be related to the change of ADM and the regulation of its specific receptor which may be one of the mechanisms for intermittent aerobic exercise in the prevention and treatment of hypertension.
