Advance in Riluzole for Spinal Cord Injury (review)
10.3969/j.issn.1006-9771.2018.06.006
- VernacularTitle:利鲁唑治疗脊髓损伤的研究进展
- Author:
Qi-Chao WU
1
;
Yan ZHANG
;
Wen-Xiu ZHANG
;
Yan-Jun ZHANG
;
Ya-Dong LIU
;
Ying-Lun ZHAO
;
Zong-Jian LIU
;
Xue-Ming CHEN
Author Information
1. 首都医科大学附属北京潞河医院
- Keywords:
spinal cord injury;
riluzole;
neuroprotection;
amyotrophic lateral sclerosis;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2018;24(6):650-653
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury (SCI) is a disabling disease usually caused by trauma. The treatment and nursing of SCI patients has brought great economic burden to the society. This article introduced the mechanism of riluzole in treating spinal cord in-jury, including blocking Na+channels, reducing glutamate-mediated excitotoxicity, promoting the expression of neuro-trophic factors, and alleviating cellular oxidative stress damage and apoptosis, and the research progress on clinical trials of riluzole.
