Gastrointestinal Motility after Spinal Cord Injury in Rats: An X-ray Study
10.3969/j.issn.1006-9771.2018.06.005
- VernacularTitle:大鼠脊髓损伤后胃肠动力的X线研究
- Author:
Chang CAI
1
;
Jian-Jun LI
;
Feng GAO
;
Ming-Liang YANG
;
Liang-Jie DU
;
De-Gang YANG
;
Chang-Bin LIU
;
Da-Peng LI
;
Wen-Hao ZHANG
;
Pei-Pei XU
Author Information
1. 首都医科大学康复医学院
- Keywords:
spinal cord injury;
neurogenic bowel dysfunction;
X-ray;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2018;24(6):645-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the dynamic changes of the intestinal function of neurogenic bowel dysfunction rats caused by spi-nal cord injury using X-ray radiography. Methods Twenty-four female Sprague-Dawley rats were divided into control group (n=12) and spinal cord injury group (n=12). The T10spinal cord injury model was established using aneurysm clip (70 grams calibration force) for 60 seconds. The control group exposed the dura only. X-ray Barium was used to observe the dynamic changes of in-testinal function, and HE staining was used to observe the pathology of the colon before and four weeks after modeling. Results Compared with the control group, gastric emptying and intestinal transit function significantly reduced in the spinal cord injury group (P<0.05). Conclusion The spinal cord injury model can be successfully duplicated with aneurysm clip in rats; neurogenic bowel dysfunction occurs after spinal cord injury, gastric emptying and intestinal transit function are weakened.
