Research Related to Neural Protection of Hypoxic and Hyperoxic Preconditioning after Spinal Cord Injury (review)
10.3969/j.issn.1006-9771.2018.01.017
- VernacularTitle:低氧预处理与高氧预处理在脊髓损伤后神经保护作用的相关研究进展
- Author:
Xiu Wen- ZHANG
1
;
Yan ZHANG
;
Jun Yan- ZHANG
;
Chao Qi- WU
;
Dong Ya- LIU
;
Jian Zong- LIU
;
Yun GUAN
;
Xue-Ming CHEN
Author Information
1. 首都医科大学附属北京潞河医院
- Keywords:
spinal cord injury;
preconditioning;
hypoxia;
hyperoxia;
vascular endothelial growth factor;
hypoxia induc-ible factor-1;
stem cells;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2018;24(1):90-92
- CountryChina
- Language:Chinese
-
Abstract:
Repeated acute intermittent hypoxia promotes the expression of growth factors and neurotrophic factors, as well as the key molecules for neural protection and plasticity. Hypoxic preconditioning may improve the survival rate of transplant-ed stem cells and protect the neural function. Meanwhile, acute intermittent hypoxia can be an approach to improve re-spiratory function after spinal cord injury. Hyperbaric oxygen may improve the neural tolerance to hypoxia and isch-emia, to protect the structure of cells and tissues, and promote the neuranagenesis. It is important to study the role of hy-poxic and hyperoxic preconditioning in spinal cord injury.
