Relationship of therapeutic effect of uterine fibroids with different intraprocedural thermal parameters during MR-guided high-intensity focused ultrasound ablation
10.13929/j.1672-8475.201711050
- VernacularTitle:MR引导下高强度聚焦超声消融子宫肌瘤温度曲线参数与治疗效果的关系
- Author:
Jia LIU
1
;
Xiaodong ZHANG
;
Rong RONG
;
Jing LIU
;
Ying ZHU
;
Xiaoying WANG
Author Information
1. 北京大学第一医院医学影像科
- Keywords:
Magnetic resonance imaging;
Ultrasound,high-intensity focused;
Uterine neoplasms;
Treatment outcome;
Thermal parameters
- From:
Chinese Journal of Interventional Imaging and Therapy
2018;15(5):268-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of therapeutic effect of uterine fibroids with different intraprocedural thermal parameters during MR-guided high-intensity focused ultrasound (HIFU) ablation.Methods Totally 31 patients with uterine fibroids underwent MR scanning.Thermometry obtained during the treatment was used to create temperature curves.Matlab software was used to analyze the temperature curve to generate several parameters,including heating slope,decay slope,area under heating curve (AUC),heating time,max temperature and time to peak.Spearman correlation test was used to observe the relationship between the shrinkage rate of uterine fibroids 6 months after ablation and the intraprocedural thermal parameters of ablation.Results Six months after ablation,the fibroid volume shrinkage rate was (39.43±27.01) ％.The temperature curve showed the mean heating slope was (0.97±0.84)℃/s,the mean decay slope was (-0.56±0.39)℃/s,the mean AUC was (2 240.03±455.93)℃ · s,the mean heating time was (28.34±12.88)s,the mean max temperature was (47.01±4.63)℃,while the mean time to peak was (22.79±9.47)s.The decay slope showed positive correlation with volume shrinkage rate 6 months after treatment (rs =0.473,P =0.007).ConclusionSlower postsonication temperature decay rate predicts better therapeutic effect of MR-guided HIFU ablation.
