Correlation of 18F-NaF micro-PET/CT and score with histopathology in collagen-induced arthritis rats

VernacularTitle:胶原诱导性关节炎大鼠18F-NaF micro-PET/CT和μCT评分与组织病理学的相关性分析
Author: He HUANG ¹ ; Wei LU ; Qin LIU ; Yifei ZENG ; Tongen ZOU ; Yue CHEN
Author Information

1. 泸州市人民医院核医学科
Keywords: Arthritis,rheumatoid; Radionuclide imaging; Tomography,emission-computed; Rats
From: Chinese Journal of Interventional Imaging and Therapy 2018;15(4):238-242
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation between 18F-NaF micro-PET/CT,μCT score and histopathology of collagen-induced arthritis (CIA) rats.Methods Seventy healthy female SD rats were randomized into CIA group (n＝50) and control group (n ＝ 20).Micro-PET/CT imaging was performed 10 days after successful modeling.Minimum standardized uptake value (SUVmin),maximum standardized uptake value (SUVmax),mean standardized uptake value (SUVmean) and μCT score were measured,and the severity of rheumatoid arthritis was assessed with histopathology.The correlations between SUVmin,SUVmax,SUV μCT score and histopathology of CIA were analyzed.Results SUVmin,SUVmax,SUVmean,μCT score of CIA all showed positive correlations with histopathology (r＝ 0.920,0.943,0.923,0.768,all P＜0.001).Conclusion 18F-NaF micro-PET/CT is a quantitative imaging method for evaluating bone erosion and bone malformation in rat rheumatoid arthritis models of CIA,which is superior to μCT examination.