Effect of catheter-based peripheral sympathetic denervation on peripheral artery sympathetic tone of New Zealand rabbits
10.13929/j.1672-8475.201708054
- VernacularTitle:腔内去交感化对新西兰大白兔外周血管张力的影响
- Author:
Bihui ZHANG
1
;
Yinghua ZOU
;
Zeyang FAN
;
Li SONG
;
Min YANG
;
Guochen NIU
Author Information
1. 北京大学第一医院介入血管外科
- Keywords:
Catheter-based peripheral sympathetic denervation;
Peripheral artery sympathetic tone;
Catheter ablation;
Peripheral arterial disease
- From:
Chinese Journal of Interventional Imaging and Therapy
2018;15(3):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of catheter-based peripheral sympathetic denervation (CPSD) on peripheral artery sympathetic tone of New Zealand rabbits.Methods Twenty New Zealand rabbits were randomly divided into CPSD group and control group (each n =10).Endovascular radiofrequency ablation above the bifurcation of the abdominal aorta was performed on the rabbits in CPSD group.Norepinephrine was infused with continuous trans-arterial pumping in both two groups.And laser Doppler flowmetry was used to measure the peripheral microperfusion and temperature of right hindlimb of rabbits.The changes of the peripheral microperfusion and temperature before (resting state) and after norepinephrine infused (norepinephrine load state) were compared between the two groups.Results Eight rabbits completed the procedure in each group.The change of peripheral microperfusion between resting and norepinephrine load states in CSPD group was lower than that in control group ([-37.19±22.56]％ vs [-57.02％±10.12]％,P=0.04),whereas the change of temperature was not significantly different between the two groups ([0.35±0.50]℃ vs [-0.21± 1.83]℃,P=0.43),while significant difference was noticed when two rabbits with abnormal temperature change in control group were neglected ([0.34± 0.50] ℃ vs [-1.14 ±0.72] ℃,P＜0.01).Conclusion CPSD can be used to decrease the peripheral artery sympathetic tone of New Zealand rabbits,and may play an important role in relieving symptoms of critical limb ischemia.
