Correlation of dynamic contrast-enhanced MRI parameters and biomarkers in breast carcinoma
10.13929/j.1672-8475.201710017
- VernacularTitle:动态增强MRI定量参数与乳腺癌生物因子的相关性
- Author:
Jing YANG
1
;
Guocai YANG
;
Jinhao LIU
Author Information
1. 青海省人民医院医学影像中心
- Keywords:
Breast neoplasms;
Magnetic resonance imaging;
Estrogen receptor;
Progesterone receptor;
Human epidermal growth factor receptor-2
- From:
Chinese Journal of Interventional Imaging and Therapy
2018;15(2):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of quantitative parameters (volume transfer constant [Ktrans],rate constant [Kep]) derived from dynamic contrast-enhanced MRI (DCE-MRI) and biomarkers of estrogen receptor (ER),progesterone receptor (PR),human epidermal growth factor receptor-2 (HER-2),Ki-67 in breast carcinoma patients.Methods Data of immunohistochemistry and pharmacokinetic parameters of 100 patients with breast carcinoma were retrospectively analyzed.The values of Ktrans,Kep among the different intensity of ER,PR,HER-2 and Ki-67 expression were compared,and the relationships were analyzed.Results No significant difference of Ktrans,Kep was found among differentintensity of ER in breast carcinoma patients (P>0.05),whereas no obvious correlation of Ktrans,Kep with ER expression was noticed (P>0.05).Ktrans,Kep had statistical differences among different intensity of PR,HER-2,Ki-67 expression in breast carcinoma patients (P<0.05),and the values of Ktrans,Kep were positively correlated with PR,Ki-67 expression (P<0.05).Conclusion The values of Ktrans,Kep were positively correlated with the intensity of PR,Ki-67 expression in breast carcinoma patients,which might provide helpful tissue characterization information.