Treatment efficacy of intracoronary microcatheter agents in the patients with no-reflow phenomenon:a Meta analysis
10.3969/j.issn.1004-8812.2018.03.007
- VernacularTitle:冠状动脉内微导管给药治疗无复流现象疗效的Meta分析
- Author:
Ye CAO
1
;
Yuan-Lin ZOU
;
Wei-Qiong WANG
;
Huan-Huan QUAN
;
Xiao-Mei GUO
Author Information
1. 华中科技大学同济医学院附属同济医院心内科
- Keywords:
No-refl ow phenomenon;
Microcatheter;
Meta analysis
- From:
Chinese Journal of Interventional Cardiology
2018;26(3):159-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the effects of intracoronary microcatheter agents in the treatment of patients with no-refl ow phenomenon. Methods Databases including Medline, EMbase, the Cochrane Library, CBM, CNKI, VIP and WanFang Data were searched electronically f rom inception to April 2017 for randomized controlled trials (RCTs) about intracoronary agents for no-reflow phenomenon. Two reviewers independently screened literatures, extracted data and assessed the risk of bias of the studies included. Meta-analysis was then performed using RevMan 5.3 software. Results A total of 8 RCTs involving 424 patients were included. The results of Meta-analysis showed that the microcatheter group had significantly better TIMI flow grade[RR=0.38,95%CI(0.27,0.52), P<0.000 01],TIMI myocardial perf usion grade[RR=0.35,95%CI(0.23,0.55),P<0.000 01],corrected TIMI f rame count[MD=-9.99,95%CI(-13.22,-6.76)P<0.000 01]and hypotension[RR=0.57,95%CI(0.35, 0.90),P=0.02] than those of the guiding catheter group. There was no statistical difference between the two groups in short period major adverse cardiovascular events and left ventricular ejection fraction.Conclusions Current evidence shows that intracoronary microcatheter agents could improve blood flow in patients with no-reflow phenomenon and has good safety. Due to the limited quantity and quality of the included studies, the above conclusion still needs to be verified by carrying out more high-quality RCTs.
