Post-exercise heart rate recovery relates to exercise capacity and prognosis in ST- elevation myocardial infarction treated with primary PCI
10.3969/j.issn.1004-8812.2018.02.004
- VernacularTitle:急性ST段抬高型心肌梗死患者直接经皮冠状动脉介入治疗运动后心率恢复与运动耐量及远期预后相关
- Author:
Jin BAI
1
;
Wei ZHAO
;
Yan-E LIU
;
Xin-Ye XU
;
Wei XU
;
Ling-Yun ZU
;
Shun-Lin XU
;
Wei GAO
Author Information
1. 北京大学第三医院心内科 卫生部心血管分子生物学与调节肽重点实验室 分子心血管学教育部重点实验室 心血管受体研究北京市重点实验室
- Keywords:
Myocardial infarction;
Autonomic function;
Heart rate recovery;
Exercise tolerance;
Prognosis
- From:
Chinese Journal of Interventional Cardiology
2018;26(2):74-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of post-exercise heart rate recovery(HRR)with exercise capacity, and the predictive value on long-term prognosis in patients of ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods A total of 260 patients were investigated from July 2011 to December 2014. All the patients were conducted cardiopulmonary exercise testing(CPET)within 30 days after STEMI, and heart rate recovery at 1 minute (HRR1)were calculated. The correlation between HRR with exercise tolerance was analysed. The median followup duration was 55 months(42,72), and the cardiovascular endpoint events were collected. Results The mean HRR1 was 26.0±12.2 beats in the whole study population who completed CPET.(1)HRR1 was positively correlated to peak oxygen uptake(VO2peak)(r=0.129, P<0.001).Multiple linear regression analysis demonstrated that VO2peak was independently positively associated with HRR1. (2) Cardiovascular endpoint events occurred in 60 cases (23.1%). Single factor screening through Cox regression model showed that decreased HRR1 (HRR1 ≤ 12 beats)(P=0.010)significantly correlated with the cardiovascular endpoint events. After adjusted by multiple factors, the risk of cardiovascular endpoint events in the group of decreased HRR(HRR1 ≤ 12 beats)was 2.671 times as the group of HRR1>12 beats. Conclusions Decreased HRR1 is associated with lower exercise tolerance, and it shows signifi cant prognostic values in increasing cardiovascular endpoint events in STEMI patients treated with primary PCI.
