Efficacy comparison of two administration methods of fluconazole in the treatment of intractable vulvovaginal candidiasis
10.11659/jjssx.03E018043
- VernacularTitle:氟康唑两种给药方法治疗难治性外阴阴道假丝酵母菌病的疗效对比
- Author:
Ling WANG
1
;
Rong LIU
;
Shou-Yu WANG
;
Yan CHEN
;
Hui LI
Author Information
1. 荆州市中心医院妇产科
- Keywords:
fluconazole;
administration methods;
intractability;
vulvovaginal candidiasis;
efficacy
- From:
Journal of Regional Anatomy and Operative Surgery
2018;27(5):364-367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the efficacy comparison of two administration methods of fluconazole in the treatment of intractable vulvovaginal candidiasis( VVC) . Methods 200 patients with intractable VVC were selected in our hospital from January 2014 to January 2017;according to the random number table,all patients were divided into single-dose group and consolidation group,each with 100 cases;the single-dose group was orally administered a single dose of 150mg fluconazole,while the consolidation group was orally administered 150mg o-ral fluconazole(1 time/d, continuous treatment for 3d, and administering it 1 time after next menstruation);the clinical symptom remission time,curative effect,adverse reaction and recurrence were compared in two groups. Results The vaginal itching,abdomen pain,vaginal se-cretion,mucosal hyperemia,edema remission time and the treatment efficiency rate,adverse reaction rate of single group and consolidation group were basically the same;and the difference was not statistically significant (P>0. 05). During the 12-month follow-up,the recurrence rate of consolidated group was significantly lower than that of single-dose group,the difference was statistically significant(P<0. 05). Con-clusion Compared with the single dose,the fluconazole consolidation therapy also has the good therapeutic efficacy and safety in the treat-ment of intractable VVC,and it can effectively reduce the recurrence of patients,so it is worth further clinical promotion.
