Efficacy and safety of pre-hospital use of hemagglutinin in patients with craniocerebral trauma and scalp laceration
10.11659/jjssx.01E018112
- VernacularTitle:院前使用血凝酶对颅脑创伤伴头皮裂伤的疗效及安全性分析
- Author:
Hua-Lei TANG
1
;
Lan YI
;
Pei-Wen ZHANG
;
Shan PENG
;
Wen-Jun CHEN
Author Information
1. 武汉市中心医院急诊科
- Keywords:
hemagglutinin;
craniocerebral trauma;
scalp laceration;
efficacy;
safety
- From:
Journal of Regional Anatomy and Operative Surgery
2018;27(4):300-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the efficacy and safety of pre-hospital use of hemagglutinin in patients with craniocerebral trauma and scalp laceration.Methods Totally 100 patients with craniocerebral trauma and scalp laceration who were admitted into our hospital from De -cember 2014 to December 2017 were selected as the object of study.These patients were divided into the hemagglutinin group and the control group with 50 cases in each group according to the random number table method.The control group was given conventional first aid treatment, while the hemagglutinin group was given pre-hospital use of hemagglutinin on the basis of conventional first aid treatment.Then,the efficacy and safety of the two groups were compared.Results The hemoglobin(Hb),hematocrit(HCT),platelet aggregation rate(PAR)of the he-magglutinin group were significantly higher than those of the control group after treatment,and the difference was statistically significant(P<0.05).The prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)levels and embolism complication rates of the hemagglutinin group and the control group were basically the same after treatment,and the difference was not statistically significant(P>0.05).The hypotension rate and poor prognosis of Glasgow outcome score(GOS)of the hemagglutinin group were significantly lower than those of the control group with statistically significant difference(P<0.05).Conclusion Pre-hospital use of hemagglutinin can effectively improve the hemostatic effect in patients with traumatic brain injury and scalp laceration,and it is beneficial to improve the hypotension and prognosis of patients with high safety.
