Clinical effects of loading doses of rosuvastatin in treatment of acute cerebral infarction and influence on cere-bral hemodynamics
10.11659/jjssx.03E017019
- VernacularTitle:负荷剂量瑞舒伐他汀对急性脑梗死的临床疗效及脑血流动力学的影响
- Author:
Jing XIAO
1
;
Yong-Xia PAN
;
Cheng-De PAN
;
Zong-Ju ZHENG
;
Lang-Min TAN
;
Kun-Yu TANG
;
Ming-Shan TANG
Author Information
1. 重庆市巴南区人民医院神经内科
- Keywords:
cerebral infarction;
rosuvastatin;
hemodynamics;
clinical effect
- From:Journal of Regional Anatomy and Operative Surgery
2018;27(2):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of loading doses of rosuvastatin in treatment of acute cerebral infarction and influence on cerebral hemodynamics.Methods One hundred and twenty-six patients of acute cerebral infarction who were admitted into hospital from January 2014 to June 2016 were selected and randomly divided into the observation group(63 cases,loading doses of rosuvastatin,40 mg per day at the first time,and then 20 mg per day)and the control group(63 cases,routine doses of rosuvastatin,10 mg per day),and one course lasted for 3 months.The NIHSS scores and Barthel index before treatment,1 month and 3 months after treatment were compared,as well as the clinical effects and cerebral hemodynamics changes 3 months after treatment.Results The NIHSS scores of the observation group at 1 month and 3 months after treatment were respectively lower than those of control group with statistical significance(P<0.05),and scores of the Barthel index of the observation group were higher than those of the control group with statistical significance(P<0.05).The total effective rate in the observation group was 88.89%,which was higher than that of the control group(77.78%),but the difference was not statistically significant(P>0.05).After the treatment,bilateral pulsation index(PI)of the observation group were lower than those of the control group (P<0.05).Systolic blood flow velocity(Vs)and mean blood flow velocity(Vm)were higher than those in the control group(P<0.05). The difference of adverse reaction between 2 groups was not statistically significant(P>0.05).Conclusion Loading doses of rosuvastatin can achieve better curative efficacy in treatment of patients with acute cerebral infarction and better improvement of cerebral hemodynamics.
