Application of multiattribute utility theory in pharmacoeconomic evaluation of anti - inflammatory and hepatoprotective therapy for chronic hepatitis B
10.3760/cma.j.issn.1008-6706.2018.22.012
- VernacularTitle:多属性效用理论在抗炎保肝治疗慢性乙型肝炎药物经济学评价中的应用
- Author:
Bin SHEN
1
;
Xinji YANG
;
Liya JIANG
;
Min DENG
Author Information
1. 嘉兴市第一医院药学部
- Keywords:
Hepatitis B;
chronic;
Compound glycyrrhizin;
Tiopronin;
Polyene phosphatidylcholine;
Economics;
pharmaceutical;
Multiattribute utility theory;
Utility value;
Contrast sensitivity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(22):2903-2906
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of multiattribute utility theory(MAUT) in pharmacoeco-nomic evaluation of anti - inflammatory and hepatoprotective therapy for chronic hepatitis B ( CHB). Methods During year 2014 - 2016,214 patients with mild to moderate CHB were selected. The patients were divided into three groups: A,B and C according to the therapeutic regimen,and they were given compound glycyrrhizin,tiopronin and polyene phosphatidylcholine to prevent inflammation and protect liver. MAUT model was constructed,the evaluation factors were determined and appropriate weight was given to each element parameter,the specific utility values for each factor were calculated,and by calculating the total utility value of final results quantitatively demonstrated the three regimens in the treatment of chronic hepatitis B. Results The total effective rates of A,B,C three groups were 78. 38％ ,69. 44％ ,79. 41％ ,respectively,the difference was statistically significant( χ2 = 5. 559,P < 0. 05). The incidence rates of adverse reaction of A,B,C three groups were 16. 22％ ,8. 33％ ,5. 88％ ,respectively. As to direct cost,group B(1430. 45 yuan) was better than group C(1494. 04 yuan) and group A (1515. 92 yuan). The hospital days of A,B,C three groups were (11. 3 ± 4. 8) d,(10. 9 ± 10. 6) d,(12. 5 ± 6. 4) d,respectively. The results of MAUT comprehensive evaluation showed that the total score value in polyene phosphatidylcholine group was the highest,and was the optimal treatment in the study. Conclusion Application of MAUT in the study of pharmacoeco-nomics is comprehensive,intuitive and flexible.
