Research progress of combined statins and clopidogrel on atherosclerotic plaques
10.3760/cma.j.issn.1008－6706.2018.20.034
- VernacularTitle:他汀类药物联合氯吡格雷对动脉粥样硬化斑块影响的研究进展
- Author:
Xiaoying LI
1
;
Borong ZHOU
;
Jianhua LUO
;
Wanli GAO
Author Information
1. 广州医科大学附属第三医院神经内科
- Keywords:
Atherosclerosis;
Statins;
Clopidogrel;
Cerebrovascular disease;
Plaques
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(20):2713-2717
- CountryChina
- Language:Chinese
-
Abstract:
Statins and antiplatelet drugs are the two cornerstones for the treatment of cerebrovascular disea －ses.This two drugs play a vital role in reducing platelet reactivity and inhibiting inflammation .Statins can effectively delay the progression of atherosclerosis ,reduce plaque volume and reduce the incidence of cerebrovascular diseases through multiple pathways .Clopidogrel is currently used primarily for anti －platelet aggregation .Some studies indicate that clopidogrel is also involved in the process of atherosclerosis ,but the mechanism is not clear .The anti－atheroscle－rosis effect of clopidogrel is often neglected , when statins are combined with clopidogrel .This article reviews the progress in the treatment of atherosclerotic plaque by statin combined with clopidogrel .
