Correlation of CYP2C19 polymorphism and clopidogrel efficacy after percutaneous coronary intervention in Zunyi of Guizhou province
10.3760/cma.j.issn.1008－6706.2018.20.001
- VernacularTitle:贵州省遵义地区经皮冠状动脉治疗术后患者CYP2C19基因多态性与氯吡格雷疗效的相关性研究
- Author:
Mu LIN
1
;
Qingqing MA
;
Yifeng TANG
;
Xiaojing HAN
;
Yunhua CHEN
;
Zhu TANG
;
Guoxian SHI
Author Information
1. 贵州航天医院中心实验室
- Keywords:
Percutaneous coronary intervention;
Gentype;
Cytochrome P－450;
Clopidogrel
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(20):2585-2589
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between CYP 2C19 gene polymorphisms and clopidogrel efficacy in coronary heart disease patients after percutaneous coronary intervention (PCI).Methods From January 2016 to December 2017,62 patients with acute coronary syndromes and treated with PCI in Guizhou Aerospace Hospital were recruited, CYP2C19 genotype, ADP －induced platelet aggregation rate and myocardial enzymes and other indicators were detected before operation .The myocardial enzymes were measured 24 hours after PCI.According to different metabolic types,the patients were grouped,the above indicators were compared.Results The CYP2C19*1/*1 was 37.10%,CYP2C19*1/*2 was 35.48%,CYP2C19*1/*3 was 11.29%,CYP2C19*2/*2 was 12.90%,CYP2C19*2/*3 was 3.23% and CYP2C19*3/*3 was 0.00%.The LDH,AST,CK,CK－MB and α－HBDH in the PCI patients after operation were significantly higher than those before operation (t＝0.019,0.040, 0.044,0.022,0.014,all P＜0.05).But ADP induced platelet aggregation rate and myocardial enzymes and other indicators among fast metabolism group,intermediate metabolic group and slow metabolic group had no statistically significant differences (all P ＞0.05).Conclusion CYP2C19 mutation frequency in the Chinese population is relatively large,the sample size of this study is less ,the relationship between clopidogrel resistance and the specific genotype can not be obtained ,it need to increase the sample size and comprehensive multi －factor consideration .
