Relationship between the expression of proto oncogene c-Ski in non-small cell lung cancer and the early metastasis of tumor

VernacularTitle:原癌基因c-Ski在非小细胞肺癌组织中的表达及与肿瘤早期转移的关系
Author: Zhaopeng HU ¹
Author Information

1. 萍乡市人民医院病理科
Keywords: Carcinoma; non-small-cell lung; Proto-oncogenes; Immunohistochemistry; Polymerase chain reaction
From: Chinese Journal of Primary Medicine and Pharmacy 2018;25(18):2324-2326
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between the expression of proto oncogene c -Ski in non-small cell lung cancer and the early metastasis of tumor .Methods From January 2015 to July 2016 , 97 patients with non -small cell lung cancer in the People's Hospital of Pingxiang were selected .The protein expression of c-Ski was examined with immunohistochemical SP and real -time PCR,the results were observed and compared.Results The positive rates of c-Ski protein and mRNA level in non -small cell lung cancer tissues and adjacent normal tissues were 18.6％and 79.4％,respectively,the difference was statistically significant (χ2 =71.80, P<0.01).The positive rate of c-Ski protein expressed in non -small cell lung cancer patients was related with age , clinical stage and pathologic classification ,the differences were statistically significant (χ2 =8.40,4.72,15.71,all P<0.05).Conclusion c-Ski may play an important role in the invasion and metastasis of non -small cell lung cancer,which can be used as a potential therapeutic target for non -small cell lung cancer in the future .