Medication adherence and clinical efficacy of inhaled glucocorticoids and leukotriene receptor antagonists in the treatment of children with bronchial asthma
10.3760/cma.j.issn.1008-6706.2018.15.022
- VernacularTitle:吸入性糖皮质激素与白三烯受体拮抗剂治疗儿童支气管哮喘的依从性和临床效果观察
- Author:
Yijie CHEN
1
;
Runji CHEN
;
Zejun LIN
Author Information
1. 汕头市潮阳区人民医院儿科
- Keywords:
Asthma;
Medication adherence;
Treatment outcome;
Budesonide;
Montelukast;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(15):1987-1989
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the medication adherence and clinical efficacy of inhaled glucocorticoids (ICS) and leukotriene receptor antagonists (LTRA) in the treatment of children with bronchial asthma ,in order to provide references for treatment options.Methods From 2015 to 2016,the clinical data of 140 cases with bronchial asthma who under the age of 14 years were retrospectively analyzed.The patients were randomly divided into the ICS group and the LTRA group according to the treatment methods ,with 70cases in each group.The patients in the ICS group were given aerosol inhalation of budesonide 1 mg added to saline 3 mL,twice per day,and reduced to inhale budesonide 0.5 mg/time,2 times/day after symptom relief.The patients in the LTRA group were given montelukast sodium chewable tablets 4mg/time at bed-time,one time a day for 3 months.According to the MARS-A compliance assessment,the compliance of patients in the treatment process was graded and the therapeutic effect was analyzed . Results In the same medication adherence , the effective treatment samples ( including good control and partial control) of the ICS group were 62 cases,and 8 cases without control and the effective rate was 98.36%.In the LTRA group,the effective treatment samples were 54 cases,and 16 cases without control and the effective rate was 89.09%. There was statistically significant difference in the effective rate between the two groups (χ2＝6.152,P＜0.05).In the same therapeutic efficacy (51 cases effective treatment of the ICS group ,54 cases effective treatment of the LTRA group),there were 50 cases with compliance in the ICS group and 62 cases in the LTRA group.The difference in the compliance was statistically significant (χ2＝7.012,P＜0.05).Conclusion All of the ICS group and the LTRA group can make effective control for childhood asthma.Through statistic process data of this experiment ,we discover that under the good medication adherence condition ,all of the treatment rates and the control level of the ICS group are better than the LTRA group.In the same therapeutic efficacy ,the medication adherence of the LTRA group is superior to the ICS group.
