Effects of surgery combined with immunochemotherapy on the peripheral blood T lymphocyte subsets and C-reactive protein in patients with single-renal clear cell carcinoma
10.3760/cma.j.issn.1008-6706.2018.15.013
- VernacularTitle:手术联合免疫化疗对单肾透明细胞癌患者外周血T淋巴细胞亚群和C反应蛋白的影响
- Author:
Liming DONG
1
;
Yanpei LI
;
Dongwei XUE
;
Yili LIU
Author Information
1. 中国医科大学附属第四医院泌尿外科
- Keywords:
Kidney neoplasms;
Immunochemistry;
T-lymphocyte subsets;
C-reactive protein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(15):1952-1955
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of surgery combined with immunochemotherapy on peripheral blood T lymphocyte subsets and C -reactive protein ( CRP) in patients with single renal cell carcinoma.Methods From June 2015 to June 2017,ninety patients with single-renal clear cell carcinoma who underwent radical resection of kidney in the Fourth Affiliated Hospital of China Medical University were selected ,and they were confirmed by preoperative ultrasound,CT and MRI diagnosis of unilateral renal space -occupying lesions.All patients were treated with kidney cancer immunochemotherapy.The peripheral blood T lymphocyte subsets and the changes of CRP levels of the patients before and after operation and after immunochemotherapy were observed.Results The CRP level of peripheral blood before operation was (9.12 ±4.98)μg/L,which after operationwas (28.29 ±10.23)μg/L,which after immunochemotherapy was (2.34 ±0.97)μg/L,the CRP level of peripheral blood after operation was higher than that before operation ,and the CRP level after immunochemotherapy was lower than that before surgery ,the difference was statistically significant ( F =6.78, P <0.05).The CD+3, CD+3CD+8,CD+4/CD+8levels before operation were (59.78 ±5.50)%,(34.56 ±6.23)%,(1.05 ±0.58)%,respectively,which after operation were (68.91 ± 7.49)%,(33.60 ±7.59)%,(0.98 ±0.76)%,respectively,which after immunochemotherapy were (62.31 ± 5.90)%,(21.90 ±4.55)%,(1.90 ±0.34)%,respectively.The CD+3level after operation was significantly higher than that before operation and after immunochemotherapy ,and the CD +3CD+8levels after immunochemotherapy were significantly lower than that before and after operation , and the CD +4/CD+8level after immunochemotherapy was significantly higher than that before and after operation ,the differences were statistically significant (F=6.98,8.12, 7.23,all P<0.05).Conclusion The immunochemotherapy can improve the expression level of peripheral blood T lymphocyte subgroup and CRP in patients with single -renal clear cell carcinoma who underwent radical resection of kidney,which can provide a reasonable basis for diagnosis and treatment of renal carcinoma .