Clinical efficacy of cinacalciclovir hydrochloride combined with low -dose calcitriol in the treatment of patients with secondary hyperparathyroidism of end stage renal disease
10.3760/cma.j.issn.1008-6706.2018.14.021
- VernacularTitle:西那卡塞联合小剂量骨化三醇治疗终末期肾病继发性甲状旁腺功能亢进的临床疗效观察
- Author:
Shengfen LIN
1
;
Runying ZHAO
;
Chaochao WANG
;
Xiaoqiao CAI
Author Information
1. 温州市中西医结合医院肾内科
- Keywords:
Hyperparathyroidism;
Kidner disease;
Calcitriol;
Sillocaine;
Phosphorus;
Calcium
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(14):1852-1855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cinacalcet combined with low －dose calcitriol in the treatment of patients with secondary hyperparathyroidism of end －stage renal disease.Methods A prospective analysis was conducted in 129 patients with end－stage renal disease and secondary hyperparathyroidism from April 2015 to August 2017 in the Department of Nephrology of Integrative Medicine Hospital of Wenzhou City,Zhejiang Province.The patients were randomly divided into 3 groups:group A received cinacalcet,group B received calcitriol, group C received cinacalcet and low－dose calcitriol for 3 months,respectively.Before and after treatment,the levels of serum phosphorus and serum calcium in the three groups were measured.The levels of parathyroid hormone and the parathyroid hormone clearance rate were measured to find out the therapeutic effect.Results The levels of serum calcium,phosphorus and total parathyroid hormone in group A were significantly lower than those before treatment(t＝3.269,2.263,4.233,all P＜0.05).PTH was significantly decreased,blood calcium and phosphorus significantly in-creased compared with those before treatment,the differences were statistically significant(t＝2.827,2.386,3.342, all P＜0.05).The phosphorus,total parathyroid hormone levels of group C were significantly decreased(t＝3.085, 5.142,all P＜0.05),and no significant change in serum calcium level(t＝0.258,P＞0.05).The total parathyroid hormone level:group B＞group A ＞group C,the whole parathyroid hormone clearance rate:group C ＞group A ＞group B,the differences were statistically significant(t ＝3.642,3.263,all P＜0.05).After treatment,the serum calcium level among the three groups had statistically significant difference,group B＞group C＞group A,the serum phosphorus level among the three groups after treatment had statistically significant difference,group B＞group A ＞group C (t＝3.265,3.332,all P＜0.05).Conclusion The combined use of cinacalcet and low－dose calcitriol in the treatment of secondary hyperparathyroidism in patients with end－stage renal disease can significantly reduce the level of parathyroid hormone and serum phosphorus,and without affecting serum calcium concentration.
