The influence of insulin therapy at different periods on pregnancy outcomes of patients with gestational diabetes
10.3760/cma.j.issn.1008-6706.2018.14.017
- VernacularTitle:不同孕周加用胰岛素对妊娠期糖尿病患者母婴结局的影响
- Author:
Hui ZHOU
1
;
Fang XIE
;
Weiling JU
Author Information
1. 太原钢铁集团(有限)公司总医院妇产科
- Keywords:
Diabetes,gestational;
Insulin;
Pregnancy outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(14):1837-1840
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of insulin therapy at different periods on pregnancy outcomes of patients with gestational diabetes mellitus (GDM).Methods From January 2014 to January 2017,86 patients with GDM in the General Hospital of Taiyuan Iron &Steel(Group)CO.LTD were chosen in the study.All of them were divided into 3 groups based on application periods of insulin:27 patients in groupⅠ(≤28 weeks),31patients in groupⅡ(28－32 weeks),28 patients in group Ⅲ(＞32 weeks).The blood glucose before delivery,duration of insulin application,weight gain and pregnancy outcomes were compared among different groups.Results Before delivery,the HbA1c of group Ⅰ was (5.2 ±0.5)%,which of group Ⅱ was (5.4 ±0.5 )%,which of group Ⅲ was (5.5 ±0.5)%,the difference was not statistically significant among the three groups (F＝0.197,P＞0.05).The duration of insulin application and weight gain during pregnancy demonstrated statistically significant differences among the three groups(F＝5.995,5.334,all P＜0.05).The rate of cesarean section in groupⅠwas 22.22%(6/27),which in group Ⅱ was 32.26%(10/31),which in group Ⅲ was 53.57%(15/28),the incidence rate of macrosomia in group Ⅰwas 3.70%(1/27),which in group Ⅱwas 9.68%(3/31),which in group Ⅲwas 14.29%(4/28),the differences among the three groups were statistically significant (χ2＝9.714,5.294,all P＜0.05 ). Conclusion The early application of insulin can shorten the application duration of insulin,as well inhibit the exces-sive weight gain during pregnancy and improve maternal and neonatal outcomes.
