Influence of Wenxin granule combined with trimetazidine on inflammatory factors and cardiac function in patients with chronic heart failure
10.3760/cma.j.issn.1008-6706.2018.14.008
- VernacularTitle:曲美他嗪联合稳心颗粒对慢性心力衰竭患者心功能及炎性指标的影响
- Author:
Juan YANG
1
;
Qiuxia ZHAO
Author Information
1. 枣庄矿业集团滕南医院心血管内科
- Keywords:
Heart failure;
Ventriculaw function;
Interleukin-6;
Tumor necrosis factor-alpha;
Trime- tazidine;
Wenxin granule
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(14):1797-1800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of Wenxin granule combined with trimetazidine on inflam-matory factors and cardiac function in patients with chronic heart failure(CHF).Methods From January 2015 to November 2016,100 patients with CHF in Tengnan Hospital of Zaozhuang Mining Industry Group were chosen,and were divided into control group and research group.The control group was treated with trimetazidine,the research group was treated with Wenxin granule on the basis of the control group.After treatment for 6 months,the clinical effects,cardiac function,inflammatory factors and adverse reactions between the two groups were compared.Results The total effective rate of the research group was higher than that of the control group,the difference was statistically significant (90.00% vs.72.00%,χ2＝5.263,P＜0.05).Before treatment,the cardiac function between the two groups had no statistically significant differences(t＝0.062,0.185,0.511,all P＞0.05).After treatment,the LVEF of the research group was higher than that of the control group,the LEVSD and LVEDd of the research group were lower than those of the control group,the differences were statistically significant (t＝12.754,7.936,7.367,all P＜0.05).Before treat-ment,the inflammatory factors between the two groups had no statistically significant differences(t＝0.145,0.156,all P＞0.05).After treatment,the levels of IL－6 and TNF－αof the research group were lower than those of the control group,the differences were statistically significant (t ＝6.366,10.473,all P ＜0.05 ).During the treatment,all patients had no adverse drug reactions such as vomiting,dizziness,irritability,nausea and so on.There was no signifi-cant change in liver and kidney function and hematuria.Conclusion Wenxin granule combined with trimetazidine can furtherly improve the inflammatory reactions and cardiac function of patients with CHF,it is conducive to the improvement of clinical efficacy.
