The change and clinical value of VEGF in the evaluation of PCI in patients with acute myocardial infarction
10.3760/cma.j.issn.1008-6706.2018.14.005
- VernacularTitle:急性心肌梗死患者介入治疗前后血管内皮生长因子水平变化及临床价值研究
- Author:
Junsheng LU
1
;
Yi ZHANG
Author Information
1. 日照市中心医院心内科
- Keywords:
Percutaneous coronary intervention;
Myocardial infarction;
Vascular endothelial growth factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(14):1787-1789
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the level of vascular endothelial growth factor(VEGF)in perioperative period of acute myocardial infarction (AMI)patients received percutaneous coronary intervention (PCI),and to analyze the predictive value of VEGF level for AMI diagnosis and revascularization after PCI.Methods From January 2015 to January 2017,90 AMI patients in Rizhao Central Hospital were selected as the observation group.During the same period,50 healthy subjects were selected as the control group.The changes of VEGF level in the observation group before and after PCI were observed and compared with those in the control group.According to PCI postoperative revascularization,the observation group was divided into blood supply complete group (A group)and blood supply incomplete group (B group),the serum VEGF levels were compared between the two groups after operation.Results The VEGF levels in the observation group before PCI,immediately after operation,2d after operation,7d after opera-tion were (249.2 ±32.1)ng/L,(329.4 ±56.1)ng/L,(276.5 ±37.1)ng/L,(256.2 ±29.4)ng/L,respectively, which were significantly higher than (109.3 ±16.3 )ng/L in the control group,there were statistically significant differences between the two groups (t＝5.626 10.325,6.885,6.115,all P＜0.05 ).The immediate postoperative VEGF level of the observation group was (329.4 ±56.1)ng/L,which was significantly higher than that before surgery (t＝5.258,P＜0.05 ).The immediate postoperative VEGF level between B group and A group had no statistically significant difference (P＞0.05 ).The serum levels of VEGF in B group at postoperative 2d,7d were (283.2 ± 38.3)ng/L,(261.2 ±21.4)ng/L,respectively,which were significantly higher than those in A group (t＝4.357, 4.529,all P＜0.05).Conclusion The serum VEGF level can sensitively reflect the indicators of coronary ischemia hypoxia and the reconstruction of endothelial injury in patients with AMI,and can be used as the basis for evaluating the effect of revascularization after PCI.
