Efficacy and safety of tetrandrine tablets and didofenac sodium tablets in the treatment of osteoarthritis
10.3760/cma.j.issn.1008-6706.2018.13.024
- VernacularTitle:汉防己甲素片联合双氯芬酸钠片治疗骨关节炎的疗效及安全性对照研究
- Author:
Wei WEI
1
;
Yingjun ZHU
;
Guodong GAO
Author Information
1. 余姚市人民医院风湿免疫科
- Keywords:
Osteoarthritis;
Tetrandrine;
Diclofenac sodium
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(13):1724-1728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of tetrandrine tablets and diclofenac sodium tablets in the treatment of osteoarthritis,thus to provide reference for the formulation of scientific and effective treatment.Methods From March 2015 to March 2016,Seventy patients with osteoarthritis in the People's Hospital of Yuyao were selected as study objects and divided into research group and control group according to the random number table method,with 35 cases in each group.The two groups were given glucosamine hydrochloride tablets treatment,the control group received diclofenac sodium tablets on the basis of treatment,while the research group received tetrandrine tablets on the basis of treatment of the control group,4 weeks for a course of treatment.The VAS score,joint tenderness index(TJS),joint swelling index (SJS),duration of morning stiffness,adverse reactions and clinical efficacy in the two groups were observed before and after treatment.Results The total effective rate in the study group was 97.14％ (34/35),which was higher than 80.00％ (28/35) in the control group,the difference was statistically significant between the two groups(x2 =23.932,P =0.001).Compared with before treatment,the VAS scores,SJS,TJS of the two groups were significantly decreased(all P ＜ 0.01).The study group compared with the control group,decreased more significantly,VAS score (t =6.78,P ＜ 0.05),SJS (t =5.78,P ＜ 0.05),TJS (t =6.65,P ＜ 0.05),and the morning stiffness time (t =6.98,P ＜ 0.05) were significantly reduced.The incidence rate of adverse reactions of the research group 5.71％ (2/35) was significantly lower than 31.43％ (11/35) of the control group(x2 =19.237,P ＜ 0.01).Conclusion Tetrandrine tablets combined with diclofenac sodium tablets in the treatment of osteoarthritis has low incidence of adverse reactions,high safety and ideal clinical effect,it can be widely used in clinical.
