Clinical observation of edaravone combined with ginkgo leaf extract and dipyridamole injection in the treatment of acute cerebral infarction
10.3760/cma.j.issn.1008-6706.2018.13.005
- VernacularTitle:依达拉奉联合银杏达莫注射液治疗急性脑梗死的临床观察
- Author:
Rongli RAO
1
;
Shouzhang WANG
Author Information
1. 浙江新安国际医院神经内科
- Keywords:
Brain infarction;
Edaravin;
Ginkgodamme injection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(13):1649-1652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of edaravone combined with ginkgo leaf extract and dipyridamole injection in the treatment of acute cerebral infarction.Methods From January 2016 to September 2017,100 patients with acute cerebral infarction in Xin'an International Hospital were selected.According to digital table method,the patients were divided into observation group and control group,with 50 cases in each group.The observation group was given edaravone combined with ginkgo leaf extract and dipyridamole injection.The control group received ginkgo leaf extract and dipyridamole injection treatment.The patients were treated for 20 days.The clinical effect of the two groups was compared.Results The total effective rate of the observation group was 90.0％,which was significantly higher than 70.0％ in the control group (x2 =16.265,P ＜ 0.05).Before treatment,the whole high blood viscosity,whole low blood viscosity,blood plasma viscosity,hematocrit and fibrinogen between the two groups had no statistically significant differences (t =0.156,1.563,0.156,1.563,1.263,all P ＞ 0.05).After treatment,the indicators in the two groups were declined.The whole high blood viscosity,whole low blood viscosity,blood plasma viscosity,hematocrit and fibrinogen in the observation group were (5.29 ± 1.25) mPa/s,(12.88 ± 3.35) mPa/s,(1.76 ± 0.28) mPa/s,(0.44 ± 0.48) and (3.48 ± 0.57) g/L,respectively,which were significantly better than those in the control group[(5.83 ± 1.54) mPa/s,(14.54 ±4.29) mPa/s,(1.89 ±0.32) mPa/s,(0.47 ±0.65),(3.76±0.89) g/L],the differences were statistically significant between the two groups(t =5.423,6.287,5.112,9.145,5.443,all P ＜ 0.05).Conclusion Edaravone combined with ginkgo leaf extract and dipyridamole injection in the treatment of acute cerebral infarction has good effect,and it is worth to be widely used in the clinical treatment.
