Changes of fibrinogen and homocysteine in patients with progressive cerebral infarction
10.3760/cma.j.issn.1008-6706.2018.13.002
- VernacularTitle:进展性脑梗死患者纤维蛋白原和同型半胱氨酸的变化及意义
- Author:
Bo ZHANG
1
;
Likun QI
Author Information
1. 青海省人民医院神经内科
- Keywords:
Brain infarction;
Fibrinogen;
Cysteine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(13):1637-1640
- CountryChina
- Language:Chinese
-
Abstract:
[Abstrract] Objective To investigate the changes of fibdnogen (Fib) and homocysteine (Hcy) in patients with progressive cerebral infarction,and their relationship with triglyceride (TG),cholesterol (TC),high-density lipoprotein(HDL-C) and low density lipoprotein(LDL-C),Methods A total of 246 patients with acute cerebral infarction with clear diagnosis and complete clinical data from department of Neurology in the People's Hospital of Qinghai Province from June 2012 to June 2015 were selected and divided into progressive cerebral infarction group (progressive group,n =61) and non-progressive cerebral infarction group (non-progressive group,n =185)according to the deterioration of their condition.The changes of Fib and Hcy in patients with progressive cerebral infarction,and their relationship with TG,TC,HDL-C and LDL-C were analyzed.Results At the 2nd,7th day after admission,the Fib and Hcy levels in the progressive group were (5.56 ± 1.14)g/L,(5.11 ± 1.35)g/L,(26.09 ± 6.47) μmol/L,(23.32 ± 5.78) μmol/L,respectively,which were significantly higher than those in the non-progressive group [(4.44 ± 0.97) g/L,(4.09 ± 0.58) g/L,(18.33 ± 5.02) μmol/L,(16.97 ± 6.31) μmol/L],the differences were statistically significant (t =7.478,5.729,9.710,6.955,all P ＜ 0.05),Pearson's correlation analysis showed that Fib bad significantly positive correlation with whole blood viscosity,whole blood reduced viscosity,plasma viscosity and hematocrit (r =0.613,0.544,0.507,0.496,all P ＜ 0.05),Hcy had significantly positive correlation with carotid intima-media thickness,TG,TG,and LDL =C (r =0.593,0.601 0.527,0.452,all P ＜ 0.05),Conclusion The levels of Fib and Hcy are closely related to progressive cerebral infarction,Fib and Hcy in patients with acute cerebral infarction can be used as detection index for progressive cerebral infarction.
