Expression of Apelin in prostate cancer tissue and its correlation with clinical prognosis
10.3760/cma.j.issn.1008-6706.2018.12.013
- VernacularTitle:爱帕琳肽在前列腺癌组织中的表达及与临床预后的相关性分析
- Author:
Wei HUA
1
;
Weide ZHONG
;
Minyao JIANG
;
Ming XI
;
Song WAN
;
Funeng JIANG
;
Yueping WAN
Author Information
1. 广州市花都区人民医院泌尿外科
- Keywords:
Prostatic neoplasms;
Peptides;
Polymerase chain reaction
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(12):1545-1548
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detecte the expression of Apelin ( APLN) in prostate cancer tissue and to investi-gate its correlation with prognosis of prostate cancer .Methods Collect prostate cancer patients in Department of Urology of Huadu District People's Hospital for 2014 -2016 years in Guangzhou .The expression of APLN was detected by real-time fluorescence quantitative polymerase chain reaction ( qRT-PCR) in 20 prostate cancer tissues and 20 adjacent normal tissues.The difference between the two groups was compared .And 104 samples of primary prostate cancer and 28 samples of benign paracancerous tissues from the Taylor database were selected to analyze its relationship with the clinical features and prognosis of the patients .Results Compared with the benign paracancerous tissue(7.26 ±0.03),APLN was up-regulated in the prostate cancer tissue (7.62 ±0.42)(t=3.824,P<0.001). The up-regulation of APLN was associated with pathological stage (t=2.942,P=0.003),metastasis(t=3.022, P<0.001),Gleason score (t =2.399,P =0.031),the biochemical recurrence -free survival(t =2.533,P =0.001 ) ,and the biochemical recurrence -free survival of the patients with higher expression of APLN was shorter than that of the patients with lower expression of APLN(χ2 =6.268,P=0.012).Conclusion The abnormal expres-sion of APLN may be associated with tumor formation and malignant progression of prostate cancer .High expression of APLN can predict the biochemical recurrence -free survival in patients with prostate cancer .
