Clinical effects and safety of terbutaline combined with budesonide atomized inhalation in the treatment of children with bronchiolitis obliterans
10.3760/cma.j.issn.1008-6706.2018.12.008
- VernacularTitle:特布他林联合布地奈德雾化吸入治疗小儿闭塞性细支气管炎的疗效及安全性探讨
- Author:
Shiwei LAI
1
;
Lieping HUANG
;
Haihong GU
;
Ji WANG
;
Qiao XU
;
Chao LI
;
Xiajiao LOU
Author Information
1. 舟山市妇幼保健院儿科
- Keywords:
Bronchiolitis obliterans;
Budesonide;
Terbutaline;
Administration;
inhalation;
Comparative effectiveness research;
Interleukin-4;
Interferon-gamma;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(12):1525-1528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects and safety of terbutaline combined with budesonide atomized inhalation in the treatment of children with bronchiolitis obliterans .Methods 140 cases of children with bronchiolitis obliterans from June 2015 to June 2017 were selected as research subjects , and they were randomly divided into control group and observation group according to the digital table ,with 70 cases in each group .The control group was given budesonide atomized inhalation alone ,and the observation group was given terbutaline combined with budesonide atomized inhalation .The clinical effects ,disappeared time of symptoms ,levels of IL-4 and INF-γbefore and after treatment and incidence rate of adverse effects in the two groups were compared .Results The excellent effective rate and total effective rate of the control group were 28.57％,78.57％,respectively,which were significantly lower than those of the observation group (44.29％,95.71％) (χ2 =9.73,8.60,all P<0.05).The disappeared time of symptoms of the observation group was significantly shorter than those of the control group ( t=2.67,3.15,2.20, 2.36,all P<0.05).The levels of IL-4 and INF-γafter treatment of the observation group were significantly higher than those of the control group and before treatment (t=2.44,2.71,3.07,3.66,2.94,3.26,all P<0.05).The incidence rates of adverse effects of the control group and the observation group were 8.57％,11.43％,respectively, there was no statistically significant difference between the two groups (χ2 =1.49,P>0.05).Conclusion Terbutaline combined with budesonide atomized inhalation in the treatment of children with bronchiolitis obliterans can efficiently control the disease progression ,shorten the clinical disease course ,regulate the levels of IL -4 and IFN-γand not aggravate the adverse drug reactions .
