Expression of Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Tonsil and Their Clinical Significance.
- Author:
Sei Young LEE
1
;
Sung Yoon PARK
;
Se Heon KIM
;
Eun Chang CHOI
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
MMP;
TIMP;
Tonsil;
Squamous cell carcinoma;
Prognosis
- MeSH:
Carcinoma, Squamous Cell;
Humans;
Matrix Metalloproteinases;
Metalloproteases;
Multivariate Analysis;
Neoplasm Metastasis;
Palatine Tonsil;
Paraffin;
Prognosis;
Recurrence;
Tissue Inhibitor of Metalloproteinase-1;
Tissue Inhibitor of Metalloproteinase-2
- From:Clinical and Experimental Otorhinolaryngology
2011;4(2):88-94
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: To investigate expressions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in squamous cell carcinoma of the tonsil and to correlate expression profiles with clinicopathological characteristics. METHODS: Paraffin blocks were obtained from 45 tonsil squamous cell carcinoma (SCC) patients, who underwent surgery as an initial treatment between 1994 and 2004, and from 20 normal controls. Expressions of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 were investigated immunohistochemically. RESULTS: The expressions of MMPs (except MMP-2) and TIMPs were found to be significantly different in tonsil SCC and normal control tissues. Furthermore, MMP-13 expression was found to be correlated with tumor invasion (P=0.05), and the expressions of MMP-9 and TIMP-1 with nodal metastasis (P=0.048, 0.031). No relation was found between MMP or TIMP expression and recurrence. However, MMP-9 expression was found to be significantly associated with 5-year survival in tonsil SCC patients by multivariate analysis (hazard ratio, 3.853; P=0.013). CONCLUSION: Significant overexpressions of multiple MMPs and TIMPs were found in tonsil SCC tissues. Furthermore, our findings suggest that MMP-9 expression might be a useful prognostic factor.
