Clinical effect of aripiprazole combined with lithium carbonate in the treatment of acute mania
10.3760/cma.j.issn.1008-6706.2018.10.029
- VernacularTitle:阿立哌唑联合碳酸锂治疗急性躁狂症临床效果分析
- Author:
Junwei PANG
1
;
Xueming XU
Author Information
1. 台州市第二人民医院精神科
- Keywords:
Antimanic agents;
Aripiprazole;
Lithium carbonate
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(10):1334-1337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effect of aripiprazole combined with lithium carbonate in the treatment of acute mania .Methods 72 patients with acute mania were selected in this research .According to the order of admission,the patients with odd numbers were selected as the control group (n=36),and the patients with even numbers were selected as the observation group (n=36).The control group was treated with clozapine combined with lithium carbonate ,the observation group was treated by aripiprazole combined with lithium carbonate .The safety and efficacy of the treatment were evaluated by BRMS score , effective rate , incidence rate of adverse reaction etc .Results After treatment for 1 week,2 weeks,the BRMS scores of the observation group were (21.23 ±2.22)points and (20.02 ±2.12)points,which were significantly lower than those of the control group (t=4.0390,4.0025,all P<0.05).After treatment for 4 and 8 weeks,the BRMS scores of the two groups were similar .The effective rate of the observation group was 94.44%,which of the control group was 91.67%,the difference was not statistically signifi-cant (P>0.05).The incidence rate of adverse reactions of the observation group was 19.44%,which was significantly lower than 41.67% of the control group,the difference was statistically significant (χ2 =11.6446,P<0.05) .Conclusion Aripiprazole combined with lithium carbonate has similar effect with clozapine combined with lithium carbonate in the treatment of acute mania ,but the combination therapy of aripiprazole and lithium carbonate can effec -tively alleviate the symptoms of the disease ,and with less adverse reaction ,high safety,which can be promoted and applicated in clinical .
