Effect of acyclovir eye drops combined with glucocorticoid in the treatment of severe viral keratitis
10.3760/cma.j.issn.1008-6706.2018.10.019
- VernacularTitle:阿昔洛韦联合糖皮质激素治疗重度病毒性角膜炎的疗效观察
- Author:
Pingyu SHEN
1
Author Information
1. 绍兴第二医院眼科
- Keywords:
Keratitis;
Viruses;
Acyclovir;
Glucocorticoids
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(10):1294-1297
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of acyclovir eye drops combined with glucocorti -coid in the treatment of severe viral keratitis .Methods 92 patients with severe viral keratitis were enrolled in this study.The patients were divided into control group and observation group according to random number table , with 46 cases in each group .The control group was treated with acyclovir eye drops ,and the observation group was treated with glucocorticoid combined with acyclovir eye drops .The clinical efficacy ,visual acuity ,adverse reactions and recur-rence of keratitis were compared and analyzed in the two groups .Results The total effective rate of the observation group was 95.65%,which was significantly higher than 67.39% of the control group,the difference was statistically significant (χ2 =12.195,P<0.05).After treatment,the visual acuity in the observation group was (0.87 ±0.31), which was significantly higher than (0.65 ±0.27) in the control group,the difference was statistically significant (t=3.630,P<0.05).The recurrence rate of the observation group was 4.35%,which was significantly lower than 21.74%of the control group (χ2 =6.133,P<0.05).The incidence rate of adverse reactions between the two groups had no statistically significant difference (P>0.05).Conclusion Acyclovir eye drops combined with glucocorticoid in the treatment of severe viral keratitis has significant treatment effect ,it can effectively improve the visual acuity of patients,reduce the recurrence rate ,improve the treatment effect ,and with high safety .
