Comparison of the effects of mesalazine oral plus enema and only oral administration in the treatment of ulcerative colitis
10.3760/cma.j.issn.1008-6706.2018.10.013
- VernacularTitle:美沙拉嗪口服加灌肠与单纯口服治疗溃疡性结肠炎的疗效比较
- Author:
Zhijun ZHAO
1
;
Xueyong YIN
;
Ying ZHANG
;
Baochun LI
Author Information
1. 秦皇岛市第二医院消化内科
- Keywords:
Mesalazine;
Enema;
Colitis;
ulcerative;
Comparative effectiveness research
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(10):1271-1274
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of mesalazine oral plus enema or only oral admin-istration in the treatment of ulcerative colitis .Methods 114 patients with ulcerative colitis were selected , and they were randomly divided into the observation group and treatment group according to random number table , with 57 cases in each group .The observation group was given mesalazine oral treatment ,and the treatment group was given mesalazine oral plus enema .The changes of CRP ,Fid,MPV after treatment were compared between the two groups .The situation of mucosa under colonoscopy , effective rate and the incidence of adverse reactions were compared between the two groups.Results After treatment,the CRP,Fid levels in the treatment group were lower than those in the observation group [(3.17 ±1.48)mg/L vs.(6.14 ±2.53)mg/L,(2.14 ±0.17)g/L vs.(2.91 ±0.27)g/L],the MPV in the treatment group was higher than that in the observation group [(10.93 ±0.59) fL vs.(10.21 ± 1.21)fL],the differences were statistically significant (t=7.650,18.220,4.038,all P<0.05).The total remission rate of the treatment group was higher than that of the observation group (100.00%vs.78.95%) (χ2 =13.412,P<0.001).The total effective rate of treatment group was higher than that of the observation group (89.47% vs .75.44%) (χ2 =3.881,P=0.049).The incidence rate of adverse reactions in the treatment group was lower than that in the observation group (3.51%vs.26.32%) (χ2 =11.683,P=0.001).Conclusion Mesalazine oral plus enema in the treatment of ulcerative colitis has good effect ,minor adverse reactions,high safety,which is worthy of clinical application .
