Effects of probiotics combined with oral scaling in the treatment of patients with chronic atrophic gastritis
10.3760/cma.j.issn.1008-6706.2018.10.012
- VernacularTitle:益生菌联合口腔洁治用于慢性萎缩性胃炎的效果观察
- Author:
Damin SHI
1
;
Rong CHEN
Author Information
1. 烟台市莱阳中心医院消化内科
- Keywords:
Gastritis;
atrophic;
Helicobacter pylori;
Oral health;
Probiotics
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(10):1267-1271
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the safety and effects of probiotics and oral scaling in the treatment of patients with chronic atrophic gastritis .Methods 180 patients with chronic atrophic gastritis were chosen as study objects.The patients were randomly divided into control group and research group according to the digital table ,with 90 cases in each group .The control group received sequential therapy and oral scaling ,the research group was given oral scaling combined with probiotics.After treatment for 3 months,the clinical effects,symptom score,pathology score,Hp clearing rate and adverse reaction between the two groups were compared.Results The total effective rate of the research group(92.22%) was higher than that of the control group (82.22%),the difference was statistically significant (χ2 =4.038,P<0.05).The gastric Hp eradication rate of the research group (96.67%) was higher than that of the control group(86.67%),the difference was statistically significant (χ2 =5.891,P<0.05).There was no statistically significant difference in positive rate of oral Hp between the two groups (P>0.05).Before treatment,the symptom score and pathology score between the two groups had no statistically significant differences (all P >0.05).After treatment,the symptom score and pathology score of the research group were ( 6.41 ±1.09 ) points, ( 5.46 ± 0.94)points,respectively,which were significantly lower than those of the control group [(7.56 ±1.18) points, (8.12 ±1.04) points],the differences were statistically significant (t =8.026,9.843,all P <0.05).7 cases (7.78%) of adverse reaction occurred in the research group ,and 5 cases(5.56%) in the control group,the differ-ence was not statistically significant between the two groups (χ2 =0.357,P >0.05).Conclusion Probiotics combined with oral scaling on the basis of sequential therapy in the treatment of patients with chronic atrophic gastritis can effectively improve the Hp clearing rate and clinical symptom ,and with good effects and safety .
