Preventive and therapeutic effects of different doses of penehyclidine hydrochloride on the catheter-related bladder discomfort during general anesthesia recovery period
10.3760/cma.j.issn.1008-6706.2018.08.018
- VernacularTitle:不同剂量盐酸戊乙奎醚防治全身麻醉苏醒期导尿管不适的效果比较
- Author:
Tianwu SHI
1
;
Wensheng HE
;
Yunyun SUN
;
Xia LI
;
Yuan HU
;
Wei JIANG
Author Information
1. 合肥市第二人民医院麻醉科
- Keywords:
Preanesthrtic medication;
Penehyclidine hydrochloride;
Catheter-related bladder discomfort
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(8):1019-1021
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive and therapeutic effects of different doses of penehyclidine hydrochloride preoperative medication on the catheter -related bladder discomfort during general anesthesia recovery period.Methods 160 adult patients who underwent general anesthesia for elective surgery were randomly dividided into four groups.40 patients in each group received intravenous injection 30min before surgery with penehyclidine hydrochloride 0.005mg/kg (group A),0.010mg/kg (group B),0.015mg/kg (group C),or normal saline (group D).All patients were catheterized with a 12 Fr Foley's catheter and the balloon was inflated with 8mL normal saline after anesthesia induction .The bladder discomfort was assessed during recovery in the post -anesthesia care unit .The severity of bladder discomfort was graded as mild , moderate and severe .Results The incidence of moderate and severe bladder discomfort in group B and group C (group B:20.0％,5.0％;group C:12.8％,2.5％) were significant lower compared with group A and group D ( group A:38.5％,12.8％;group D:46.0％ 15.4％) (χ2 =7.834, 6.764,8.163,14.172,8.362,6.943,15.413,17.512,all P<0.05).There was no significant difference between group B and group C , group A and group D .Conclusion Hydrochloride penehyclidine preoperative administration with 0.010mg/kg or 0.015mg/kg can effectively control the incidence of catheter discomfort during general anesthesia recovery period and 0.010mg/kg is appropriate for the elderly .
