Clinical effect of retinal photocoagulation combined with drug on retinopathy of diabetic retinopathy and its effect on VEGF and IGF-1 level
10.3760/cma.j.issn.1008-6706.2018.08.004
- VernacularTitle:视网膜光凝术联合药物治疗糖尿病视网膜病变疗效及其对血管内皮生长因子、类胰岛素一号增长因子水平的影响
- Author:
Gaochun LI
1
;
Xianping LIN
;
Ledan WANG
;
Enhui LI
Author Information
1. 浙江省台州医院眼科
- Keywords:
Laser coagulation;
Diabetic retinopathy;
Vascular endothelial growth factors;
Insulin-like growth factor-1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(8):965-968
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and application value of retinal photocoagulant combined with compound anisodine in the treatment of diabetic retinopathy , and its effect on vascular endothelial growth factor (VEGF) and insulin-like growth factor-1(IGF-1) level.Methods 116 patients with diabetic retinopathy were selected ,and they were randomly divided into observation group and control group according to the digital table ,58 cases in each group .The control group was given retinal photocoagulation treatment , and the observation group was given retinal photocoagulation combined with compound anisodine treatment .The therapeutic effect was compared between the two groups.Results The total effective rate of the observation group was 93.10％,which was significantly higher than 77.59％ of the control group, and the difference between the two groups was statistically significant (χ2 =5.582,P<0.05).The edema absorption time,bleeding absorption time,exudate absorption time of the observation group were (4.19 ±1.24) d,(2.19 ±1.01) d,(9.48 ±2.13) d,respectively,which of the control group were (5.83 ±2.85)d,(3.25 ±1.88)d,(13.54 ±3.88)d,respectively,and the differences between the two groups were statistically significant (t=4.018,3.782,6.985,all P<0.05).After treatment,the VEGF and IGF-1 levels in the observation group were (85.12 ±4.64) ng/L,(90.17 ±4.95)μg/L,respectively,which in the control group were (100.48 ±9.26)ng/L,(132.69 ±10.04)μg/L,respectively,the differences between the two groups were statistically significant (t=11.294,28.928,all P<0.05).Conclusion Retinal photocoagulation surgery combined with compound anisodine in the treatment of diabetic retinopathy can improve clinical curative effect ,promote the patients'visual acui-ty,adjust the concentration of VEGF ,the effect is remarkable ,it is worthy of popularizing in clinical application .
