MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization.
10.3346/jkms.2015.30.7.965
- Author:
Seungsoo LEE
1
;
Kyung Ah KIM
;
Mi Suk PARK
;
Sun Young CHOI
Author Information
1. Department of Radiology, Research Institute of Radiological Science, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Transcatheter Arterial Chemoembolization;
Drug-eluting Beads;
Carcinoma, Hepatocellular;
Magnetic Resonance Imaging;
Subtraction Image
- MeSH:
Adult;
Aged;
Antineoplastic Agents/administration & dosage/*therapeutic use;
Carcinoma, Hepatocellular/*drug therapy;
*Chemoembolization, Therapeutic;
Disease Progression;
Drug Carriers/*pharmacology;
Female;
Humans;
Liver Neoplasms/*drug therapy;
Magnetic Resonance Imaging;
Male;
Microspheres;
Middle Aged;
Multidetector Computed Tomography;
Treatment Outcome
- From:Journal of Korean Medical Science
2015;30(7):965-973
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression (TTP). This study included 48 patients with 60 lesions who underwent liver MRI within 3 months after DEB-TACE. MRI was assessed for arterial enhancement pattern, late washout, arterioportal shunt, signal intensity on T2-weighted image, intratumoral septa, enhancing tissue on subtraction images, and treatment response. Cox-regression analysis was performed to identify independent factors to predict TTP. TTP was calculated using the Kaplan-Meier method with the log-rank test. Per lesion, 30 achieved complete remission, 22 had a partial response, and the remaining 8 lesions displayed stable disease on MRI. Arterial enhancement pattern, washout and enhancing tissue on subtraction images from MRI were associated with viable tumor on the last follow-up computerized tomography. Arterial enhancement, washout and enhancing tissue on subtraction images were significant predictors of TTP, but only enhancing tissue on subtraction images remained a significant predictor of TTP (P=0.018) in the multivariate analysis. TTP was longer in the group without enhancing tissue on subtraction images compared to the group with enhancing tissue (601 days vs. 287 days, P<0.001). Enhancing tissue on subtraction images from MRI after DEB-TACE is predictive for longer TTP.
