Effects of ambroxol hydrochloride injection combined with pulmonary surfactant on the improvement of arterial blood gas index and the time of mechanical ventilation in neonates with respiratory distress syndrome
10.3760/cma.j.issn.1008-6706.2018.05.020
- VernacularTitle:盐酸氨溴索注射液联合肺表面活性物质对新生儿呼吸窘迫综合征患儿动脉血气指标改善及机械通气时间的影响
- Author:
Liyun MAO
1
;
Yanlei WU
;
Jiangang WU
Author Information
1. 建德市第一人民医院儿科
- Keywords:
Respiratory distress syndrome;
newborn;
Pulmonary surfactant-associated proteins;
Ambroxol hydrochloride injection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(5):620-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ambroxol hydrochloride injection combined with pulmonary surfactant(PS) on the improvement of arterial blood gas index and the time of mechanical ventilation in neonates with respiratory distress syndrome (NRDS).Methods 82 children with NRDS were selected,and they were randomly divided into two groups according to the digital table ,41 cases in each group.The control group received 100mg/kg PS inhalation,and the study group received intravenous injection of 7.5mg/kg ambroxol hydrochloride +100mg/kg PS inhalation.The changes of arterial blood gas index [PaO2 ,arterial carbon dioxide pressure ( PaCO2 ),pH value], mechanical ventilation time,oxygen supply time and hospitalization time were statistically compared between the two groups.Results The PaO2 [(89.38 ±4.72)mmHg]and pH value (7.40 ±0.02) of the study group were higher than those of the control group [(66.42 ±5.58) mmHg,(7.32 ±0.04)] at 12h after treatment,while PaCO2 [(29.04 ±4.63)mmHg]was lower than that in the control group [(35.38 ±5.67)mmHg],and the differences were statistically significant(t =20.115,11.454,5.545,all P =0.000).The hospitalization time,oxygen supply time and mechanical ventilation time of the study group were lower than those of the control group [(11.10 ±3.47) d vs. (18.61 ±8.72)d,(7.49 ±5.31) d vs.(14.32 ±11.61) d,(56.21 ±11.78)h vs.(78.22 ±18.31)h],and the differences were statistically significant (t =5.123,3.425,6.473,all P =0.000).Conclusion Ambroxol hydrochlo-ride injection combined with PS can improve the arterial blood gas index in children with NRDS and shorten the time of mechanical ventilation,hospitalization and oxygen supply .
