Clinical effect of botulinum toxin in the treatment of spastic pediatric cerebral palsy and its effect on prognosis
10.3760/cma.j.issn.1008-6706.2018.05.018
- VernacularTitle:肉毒杆菌毒素治疗痉挛型小儿脑瘫的临床效果及其对预后的影响
- Author:
Fenghuan DUAN
1
;
Zhenxiang ZHANG
Author Information
1. 271500,山东省东平县人民医院儿科
- Keywords:
Cerebral palsy;
Spasm;
Botulinum toxins,type A
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(5):613-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of botulinum in the treatment of spastic pediatric cerebral palsy,and to analyze its effect on the prognosis of patients .Methods 80 patients with cerebral palsy were enrolled in this study.The patients were divided into study group and control group according to the random number table method,40cases in each group.The control group was given routine treatment .The study group was treated with botulinum toxin on the basis of routine treatment .The clinical treatment effect of the two groups was observed and the prognosis was analyzed.Results The Ashworth scores and GMFM scores of the study group and the control group were (1.21 ±0.04)points vs.(2.12 ±0.08) points,(63.17 ±6.37) points vs.(56.12 ±7.13) points,the differ-ences between the two groups were statistically significant (t =4.215,11.042,all P <0.05).The activities of poplite-al fossa angle,foot abduction angle and dorsiflexion angle in the study group and the control group were (100.31 ± 9.42)°vs.(117.21 ±10.26)°,(118.35 ±9.33)°vs.(101.13 ±9.22)°,(70.12 ±8.41)°vs.(83.16 ±9.37)°, the differences between the two groups were statistically significant (t =13.217,11.473,7.295,all P <0.05).The scores of life,cognition,social and verbal quality of life of the study group and the control group were (67.93 ± 3.51)points vs.(52.12 ±3.09)points,(56.23 ±4.21)points vs.(45.21 ±3.01)points,(58.35 ±3.11)points vs. (42.68 ±3.06)points,(54.13 ±3.74)points vs.(38.12 ±3.27)points,the differences between the two groups were statistically significant(t =5.093,4.337,4.012,3.972,all P <0.05).Conclusion The clinical application of botulinum to children with cerebral palsy is feasible,it can improve motor function,and effectively improve the prognosis of children.
